PIGS: a resource for immunoglobulin structure prediction

Abstract

Pigs (http://arianna.bio.uniroma1.it/pigs) is a web server for the automatic modeling of immunoglobulin variable domains based on the canonical structure method. It has a user-friendly and flexible interface, that allows the user to choose templates (for the frameworks and the loops) and modeling strategies in an automatic or manual fashion. Its final output is a complete three-dimensional model of the target antibody that can be downloaded or displayed on-line. The server is freely accessible to academic users, with no restriction on the number of submitted sequences.