Alterations of Choline Phospholipid Metabolism in Ovarian Tumor Progression: a NMR study

Authors

  • Alessandro RICCI Istituto Superiore Sanità - Roma
  • Egidio Iorio Istituto Superiore Sanità
  • Franca Podo Istituto Superiore Sanità

Keywords:

ovarian cancer, choline phospholipid metabolism, NMR, choline kinase, phosphocholine, phospholipase.

Abstract

In the present study, we quantified the intracellular levels of PC metabolites in the progression from non-tumoral ovarian surface epithelial (OSE) cells or immortalized cell variants to ovarian cancer cell lines and related these levels to quantitative differences in the basal activity of enzymes involved in PC biosynthesis and/or catabolism. In particular, the choline kinase (chok) basal activity rate and the overall PC-specific phospholipases C and D (PC-plc and PC-pld) activity were evaluated.

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Published

18-02-2008

How to Cite

RICCI, A., Iorio, E., & Podo, F. (2008). Alterations of Choline Phospholipid Metabolism in Ovarian Tumor Progression: a NMR study. Biophysics and Bioengineering Letters, 1(1). Retrieved from https://rosa.uniroma1.it/rosa00/index.php/biophysics_and_bioengineering/article/view/2782

Issue

Vol. 1 No. 1 (2008)

Section

Section 2: Biophysics PhD

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