Advanced morphological and analytical methods play a very important role in paleopathological investigation. Depending on the availability of the instruments, a modern pathologist should be prepared to choose the most suitable technique to the specific question and be able to interpret the results obtained. The aim of this paper is to illustrate the application of such methods through a series of practical examples dating back from Egyptian dynastic to contemporary mummified tissues, in order to outline a basic guideline for paleopathologists in different settings.
