The documents concerns the following topics: the studies performed by the Italian Ministry of Agriculture, Industry and Commerce between 1870 and 1890 on the causes of unhealthiness of the lands around Rome and the methods to remove them, i.e. irrigation canals and agricoltural trasformations; the role played by the General DIrection of the Land reclamation of the Ministry of Agricolture and Forests from 1929 in the realization of the interventions of hydraulic and antianopheles reclamation addressed to modify the enviromental conditions, and in the realization of assistants services and antimalaria prophylaxis in the relamation zones.