The Construction of the Genetic Order: A Short Critical History
DOI:
https://doi.org/10.13133/2532-5876/17021Abstract
Genetics, as all human activities, is a situated practice. Given its enormous cultural and epistemological influence, the young age of the discipline may be surprising - not even 150 years old. The creation of the science of the heredity and production of traits in organisms responded to 19th century’s epistemological needs in biology, as well as political and social developments: the transmission of characters and their variations throughout generations needed a new theory, the embryological development of organisms had to be explained, the unrest and disastrous living conditions provoked by the industrial capitalism and the colonial project in the West called for a reaction from the elites. The trajectory of genetics is one of permanent co-production between the different ontologies and practices it is situated in. As a science, it draws its legitimacy from the stories it tells (about the world or about itself), the interests it serves and the existing power relations it is part of. Given this background, the present work tries to shed some light on several aspects of the history of genetics that may help clarify its role and impact on our societies. The set of ontological and material transformations it underpins is referred to as the Genetic Order, and this is explored particularly in the context of the irremediable past and present association of genetics with eugenics, the construction of key notions such as heritability and the dichotomy Nature/Nurture, the enormous influence of cybernetics over biology and genetics after the second world war and the alliance between biotechnologies, genetics and neoliberalism in more recent years. One key notion that wanders throughout this text is that of control, over bodies and life in general. This is illustrated by the recent explosion of the genomic prediction industry and its impact on contemporary subjectivities. In the end, it is a world of statistics, algorithms, predestination, risk management and control that the Genetic Order offers, echoing the hegemonic influence of the neoliberal cybernetic project where all that lives must be engineered, modelled, monitored, predictable and transparent.
References
Aguiton, SA 2018, La démocratie des chimères: gouverner la biologie synthétique, Collection “Objets d’histoire,” Le Bord de l’eau, Lormont.
Benasayag, M 2016, Cerveau augmenté, homme diminué, La découverte, Paris.
Bizzarri, M, Palombo, A & Cucina, A 2013, 'Theoretical aspects of Systems Biology', Progress in Biophysics and Molecular Biology, vol. 112, no. 1–2, pp. 33–43.
Bliss, C 2018, Social by nature: the promise and peril of sociogenomics, Stanford University Press, Stanford, California.
Bonneuil, C 2019a, Seeing nature as a ‘universal store of genes’: How biological diversity became ‘genetic resources’, 1890–1940. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences Volume 75, 1-14.
— 2019b, "How not to govern the living?” Vassivières, http://radiovassiviere.com/2019/05/enregistrements-des-conferences-des-journee-detudes-habiter-etre-habite-e-quelles-relations-au-vivant/
— 2015a, “Le siècle du gène” in C. Bonneuil et D. Pestre (dir), Histoire des sciences et des savoirs. 3. Un siècle de technosciences (depuis 1914), Paris, Seuil, 297-317.
— 2015b, “Une nature liquide ? Les discours de la biodiversité dans le nouvel esprit du capitalisme” in F. Thomas et V. Boisvert (dir), Le pouvoir de la biodiversité. Néolibéralisation de la nature dans les pays émergents, Paris, Quae, pp. 193-213.
Boskovic, A & Rando, OJ 2018, 'Transgenerational Epigenetic Inheritance', Annu. Rev. Genet., vol. 52, no. 1, pp. 1–21.
Burian, RM 2013, 'Qu’est-ce qu’un gène : la fin d’une évidence ? ' In Kupiec J.-J. (ed.), La vie, et alors ? Débats passionnés de l'Antiquité à nos jours, Paris: Belin, 115-130, 391.
Calude, CS & Longo, G 2017, 'The Deluge of Spurious Correlations in Big Data', Foundations of Science, vol. 22, no. 3, pp. 595–612.
Carnino, G 2015, L’invention de la science: la nouvelle religion de l’âge industriel, L’univers historique, Éditions du Seuil, Paris.
Club of Rome, 1972, “The Limits to Growth.” http://www.donellameadows.org/wp-content/userfiles/Limits-to-Growth-digital-scan-version.pdf
Cooper, M 2008, Life as surplus: biotechnology and capitalism in the neoliberal era, In vivo, University of Washington Press, Seattle.
Crick, F 1958, On Protein Synthesis. Symposia of the Society for Experimental Biology 12, (1958): 138-163.
Davies, G, Marioni, RE, Liewald, DC, Hill, WD, Hagenaars, SP, Harris, SE, Ritchie, SJ, Luciano, M, Fawns-Ritchie, C, Lyall, D, Cullen, B, Cox, SR, Hayward, C, Porteous, DJ, Evans, J, McIntosh, AM, Gallacher, J, Craddock, N, Pell, JP, Smith, DJ, Gale, CR & Deary, IJ 2016, 'Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)', Molecular Psychiatry, vol. 21, no. 6, pp. 758–767.
de Vries, Hugo, 1889. Intracellulare Pangenesis. Jena, Gustav Fisher, 1889 [traduction anglaise : Intracelluar Pangenesis. Chicago, Court Publishing, 1910]
Delphy, C 2008, Classer, dominer: qui sont les “autres” ?, La Fabrique éd, Paris.
— 1993, 'Rethinking sex and gender', Women’s Studies International Forum, vol. 16, no. 1, pp. 1–9.
Duster, T 2003, Backdoor to eugenics, 2nd ed, edn, Routledge, New York.
Federici, S 2016, ’In praice of dancing bodies’ In A Beautiful Resistance: Everything We Already Are, Gods&Radicals Journal, Issue 1.
Foucault, M & Gordon, C 1980, Power/knowledge: selected interviews and other writings, 1972-1977, 1st American ed, edn, Pantheon Books, New York.
Gayon, J 2016, 'From Mendel to epigenetics: History of genetics', Comptes Rendus Biologies, vol. 339, no. 7–8, pp. 225–230.
Gerstein, MB, Bruce, C, Rozowsky, JS, Zheng, D, Du, J, Korbel, JO, Emanuelsson, O, Zhang, ZD, Weissman, S & Snyder, M 2007, 'What is a gene, post-ENCODE? History and updated definition', Genome Research, vol. 17, no. 6, pp. 669–681.
Keller, EF 2010, The mirage of a space between nature and nurture, Duke University Press, Durham, NC.
— 2000, The century of the gene, Harvard University Press, Cambridge, Mass.
Koshland, D 1989, 'Sequences and consequences of the human genome', Science, vol. 246, no. 4927, pp. 189–189.
Kupiec, J-J 2019, Et si le vivant était anarchique: la génétique est-elle une gigantesque arnaque?, Les Liens qui libèrent, Paris.
— 2012, L’ontophylogenèse: évolution des espèces et développement de l’individu, Sciences en questions, Éditions Quae, Versailles.
— 2010, 'On the lack of specificity of proteins and its consequences for a theory of biological organization', Progress in Biophysics and Molecular Biology, vol. 102, no. 1, pp. 45–52.
— 2009, The origin of individuals, World Scientific, New Jersey.
Kupiec, J-J & Sonigo, P 2000, Ni Dieu ni gène: pour une autre théorie de l’hérédité, Science ouverte, Seuil, Paris.
Lafontaine, C 2014, Le corps-marché: la marchandisation de la vie humaine à l’ère de la bioéconomie, La couleur des idées, Éditions du Seuil, Paris.
— 2004, L’empire cybernétique. Des machines à penser à la pensée machine, Le Seuil, Paris.
Latour, B 1993, We have never been modern, Harvard University Press, Cambridge, Mass.
Lewontin, RC 1991, Biology as ideology: the doctrine of DNA, Anansi, Toronto.
Lippman, A 1993, 'Prenatal Genetic Testing and Geneticization: Mother Matters for All', Fetal Diagnosis and Therapy, vol. 8, no. 1, pp. 175–188.
— 1991, 'Prenatal genetic testing and screening: constructing needs and reinforcing inequities', American Journal of Law & Medicine, vol. 17, no. 1–2, pp. 15–50.
Louart, B 2018, Les êtres vivants ne sont pas des machines, La Lenteur, edn.
Mayr, E 1982, Histoire de la biologie: diversité, évolution et hérédité, Fayard, Paris.
McKinnon, S 2005, Neo-liberal genetics: the myths and moral tales of evolutionary psychology, Paradigm, Prickly Paradigm Press, Chicago.
Moore, DS 2012, 'REVIEW Evelyn Fox Keller: The Mirage of a Space Between Nature and Nurture: Duke University Press, Durham, NC, 2010, Science & Education, vol. 21, no. 4, pp. 583–590.
Morange, M 2017, Une histoire de la biologie, Points, Paris.
— 2003, Histoire de la biologie moléculaire, Découverte/Poche, Paris.
Nelkin, D & Lindee, MS 2004, The DNA mystique: the gene as a cultural icon, Conversations in medicine and society, University of Michigan, Ann Arbor.
Newman, SA 2013, 'The Demise of the Gene', Capitalism Nature Socialism, vol. 24, no. 1, pp. 62–72.
Nicholson, DJ 2014a, 'The machine conception of the organism in development and evolution: A critical analysis', Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, vol. 48, pp. 162–174.
— 2014b, 'The Return of the Organism as a Fundamental Explanatory Concept in Biology: The Return of the Organism', Philosophy Compass, vol. 9, no. 5, pp. 347–359.
Noble, D 2017, Dance to the Tune of Life: Biological Relativity, 1st edn, Cambridge University Press.
— 2015, 'Evolution beyond neo-Darwinism: a new conceptual framework', Journal of Experimental Biology, vol. 218, no. 8, pp. 1273–1273.
— 2011, 'Neo-Darwinism, the Modern Synthesis and selfish genes: are they of use in physiology?: Neo-Darwinism, the Modern Synthesis and selfish genes', The Journal of Physiology, vol. 589, no. 5, pp. 1007–1015.
— 2008, 'Genes and causation', Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 366, no. 1878, pp. 3001–3015.
Pichot, A 2010, "Le racisme scientifique". Nantes, https://www.youtube.com/watch?v=UhXnLSH1O2s
— 2009, La société pure: de Darwin à Hitler, Flammarion, Paris.
— 2003 Mémoire pour rectifier les jugements du public sur la révolution biologique. Revue Esprit. Aout-septembre, p104
— 2002 Notion de programme génétique. Philosophia Scientiae, 6 (1), 2002, 163—172.
— 2001 La génétique est une science sans objet. Revue Esprit. Mai, p102
— 1999, Histoire de la notion de gène, Champs, Flammarion, Paris.
— 1996 Hérédité et évolution (l'inné et l'acquis en biologie). Revue Esprit. Juin, p7
Rautiainen, M-R, Paunio, T, Repo-Tiihonen, E, Virkkunen, M, Ollila, HM, Sulkava, S, Jolanki, O, Palotie, A & Tiihonen, J 2016, 'Genome-wide association study of antisocial personality disorder', Translational Psychiatry, vol. 6, no. 9, pp. e883–e883.
Rosanvallon, J 2012, 'Pure variation and organic stratification', Progress in Biophysics and Molecular Biology, vol. 110, no. 1, pp. 137–149.
Rouvroy, A 2008, Human genes and neoliberal governance: a Foucauldian critique, Routledge-Cavendish, New York.
Royer, J-M 2017, Le monde comme projet Manhattan: des laboratoires du nucléaire à la guerre généralisée au vivant, Éditions le Passager clandestin,
Lyon.
Said, EW 1995, Peace and its discontents: essays on Palestine in the Middle East peace process, 1st ed, edn, Vintage Books, New York.
Sanders, AR, Beecham, GW, Guo, S, Dawood, K, Rieger, G, Badner, JA, Gershon, ES, Krishnappa, RS, Kolundzija, AB, Duan, J, Gejman, PV, Bailey, JM & Martin, ER 2017, 'Genome-Wide Association Study of Male Sexual Orientation', Scientific Reports, vol. 7, no. 1, p. 16950.
Schrödinger, E 1944, What Is Life?, Cambridge University Press.
Sonigo, P 2013, "Ondes et Particules de vie", https://www.canal-u.tv/video/iea/conference_de_pierre_sonigo_ondes_et_particules_de_vie.13281
Sonigo, P & Stengers, I 2003, L’évolution, EDP Sciences, edn.
The invisible committee 2017, Now, Semiotext(e) intervention series, Semiotext(e), South Pasadena, CA.
— 2015, To our friends, Semiotext(e) intervention series, Semiotext(e), South Pasadena, CA.
Tiqqun 2020, Cybernetic hypothesis, Semiotext(e), Los Angeles
Downloads
Published
How to Cite
Issue
Section
License
Copyright Agreement with Authors
Before publication, after the acceptance of the manuscript, authors have to sign a Publication Agreement with Organisms. The authors retain all rights to the original work without any restrictions.
License for Published Contents
You are free to copy, distribute and transmit the work, and to adapt the work. You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work).